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In a modern review, we claimed the identification as well as characterization of a different atypical opioid receptor with exceptional unfavorable regulatory Qualities to opioid peptides.1 Our outcomes confirmed that ACKR3/CXCR7, hitherto known as an atypical scavenger receptor for chemokines CXCL12 and CXCL11, is usually a broad-spectrum scavenger